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Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you need to err assisting caution and allow FDA do its job and demand some investigation be done so that the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on their own medications. Researchers found out that participants taking this drug to get a year, lost weight within 4 weeks and have kept the load off throughout the 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which might make them more potent and safer. Combo-pilling is the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular may be the fact that by right now there are not any long term prescription diet pills that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug also can raise blood pressure and heartrate, and mustn't be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must 't be used in patients with uncontrolled high blood pressure levels, as well as by you are not heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. From a psychiatric viewpoint, evidence points too the ordinary neural mechanism for goal-directed behavior has been hijacked by the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus and also the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).