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Using two separate drugs to shed pounds can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you need to err along the side of caution and allow the FDA do its job and demand some study be done in order that the public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to make money and that they would say almost anything to keep people on their medications. Researchers discovered that participants investing in this drug to get a year, dropped a few pounds within one month and have kept the extra weight off through the entire 56 weeks with the study. Contrave can be a combination with the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which are made up of many active ingredient, that might make them more efficient and safer. Combo-pilling will be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that by right now there aren't long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug also can raise blood pressure level and heart rate, and mustn't be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and pulse rate and must not used in patients with uncontrolled high blood pressure levels, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. "There were no indications of depression or suicidal thoughts in trial participants," said Fujioka.